Research
The Clalit Health Services Genomic Center and Laboratory serves as a leading hub for personalized medicine, performing advanced, large-scale genetic sequencing tests, including Whole Exome Sequencing (WES), Whole Genome Sequencing (WGS), and other cutting-edge methods. Operating with state-of-the-art technologies and advanced bioinformatics infrastructure, the center provides professional solutions for all Clalit institutes and clients. Its activities are carried out in close collaboration with genetic institutes, hospitals, and research entities, integrating advanced clinical and scientific knowledge. The center conducts thousands of tests annually, leading innovation in genetic sequencing and contributing to research and development to enhance diagnostic and therapeutic quality for patients.
We pride ourselves on utilizing state-of-the-art technologies to deliver exceptional results for our patients. Our advanced capabilities include whole exome sequencing,
whole genome sequencing, and
long-read sequencing,
ensuring comprehensive and accurate analysis. With cutting tools like NovaSeq, we are equipped to provide the quality insights and solutions tailored to your needs.
"Machar" Biobank
The "Tomorrow" (Machar) Biobank and Database integrates comprehensive clinical data with biological samples to accelerate medical research and practical clinical solutions. By linking advanced genomic sequencing directly to detailed longitudinal health records under strict ethical and privacy standards, this unique infrastructure enables multi-dimensional analysis into disease mechanisms and the interplay between genetic and environmental factors. Beyond basic scientific inquiry, the initiative drives personalized medicine and pharmacogenomics by tailoring drug therapies to individual genetic profiles to maximize efficacy and reduce adverse effects. Ultimately, it bridges the gap between laboratory research and clinical care, rapidly translating genomic discoveries into enhanced diagnostic tools, targeted therapeutics, and data-driven medical decision-making.
Clinical Bioinformatics Department
The Bioinformatics Department at Clalit's Genomic Center is responsible for analyzing clinical genetic tests, including the processing of sequencing data as well as variant identification and annotation. Additionally, the department develops and maintains advanced diagnostic pipelines for various genomic tests, ensuring reliability and continuous quality control. Its operations also encompass large-scale data infrastructure management, population-level data storage and analysis, alongside supporting data-driven genomic research and medical applications. The department supports variant classification by developing knowledge systems and interpretation decision-support tools, integrating AI-based solutions to link phenotype to genotype and assist in diagnostic prioritization. Finally, it serves as a cross-disciplinary interface, translating clinical and laboratory needs into advanced computational solutions.
Publications
2026
Rotem Greenberg, Ofer Isakov, Bella Davidov, Morad Khayat, Shirly Amar, Atalia Shtorch- Asor, Jumana Haddad Halloun, Sarit Farage Barhom, Daphne Chapman Shimshoni, Dana Brabbing-Goldstein, Maria Karter, Yael Avigdor, Isabelle Espanioly, Valerie Drasinover, Olga Krivoruk, Harel Zalts, Rivka Sukenik-Halevy, Shira Litz Philipsborn, Ran D Balicer, Shay Ben-Shachar
Journal of Medical Gentics
2026
Ofer Isakov, Reut Ashwal-Fluss, Dina Marek-Yagel, Shamil Sunyaev, Shay Ben-Shachar
Genetics in Medicine
2026
Dina Marek-Yagel, Rotem Greenberg, Michal Naftali, Shay Ben Shachar, Ofer Isakov
The Journal of Molecular Diagnostics
2026
Tom Mushkat, Rotem Greenberg, Ofer Isakov, Samah Hayek, Hadassah Raskas, Shay Ben-Shachar, Adi Berliner-Senderey
European Journal of Public Health
2026
Asier Iturrate, Nurit Assia Batzir, Ranit Jaron, David Garcia-Valentin, Julian Nevado, Jair Tenorio-Castano, Pablo Lapunzina, Kamila Lee, Rotem Greenberg, Dvora Sassi, Sharon Aharoni, Alla Kuzminsky, Lina Basel-Salmon, Naama Orenstein, Yakov Fellig, Shay Ben-Shachar, Dina Marek-Yagel, Victor L Ruiz-Perez
European Journal of Human Genetics
2025
Rotem Greenberg, Noa Shefer Averbuch, Lena Sagi-Dain, Idit Maya, Noa Ruhrman Shahar, Nesia Kropach-Gilad, Dina Mark-Yagel, Ran D Balicer, Shay Ben Shachar
Genetics in Medicine
2025
Liraz Klausner, Shai Carmi, Shay Ben-Shachar, Noa Lev-El Halabi, Lina Basel-Salmon, Dana Brabbing-Goldstein
Genetics in Medicine
2025
Noa Ruhrman Shahar, Dina Marek-Yagel, Rotem Greenberg, Ofer Isakov, Michal Naftali, Elena Friedman, Lily Bazak, Daniel Monakier, Alvit Veber, Nechama Shalva, Amitai Segev, Moti Haim, Lena Sagi-Dain, Lilach Benyamini, Adel Shalata, Sagi Josefsberg Ben Yehoshua, Lina Basel Salmon, Sara Hoss, Shay Ben-Shachar
Circulation: Genomic and Precision Medicine
2023
Rotem Greenberg, Ofer Isakov, S Ben Shahar, Lena Sagi-Dain