Genomic Center
1
Gene Therapy
12 ONGOING RESEARCH PROJECTS
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2
Oncology
5 ONGOING RESEARCH PROJECTS
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3
Drug Discovery & Delivery
8 ONGOING RESEARCH PROJECTS
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Publications
Pan-ethnic preconception screening: evidence from a large-scale programme in a genetically diverse population
Rotem Greenberg, Ofer Isakov, Bella Davidov, Morad Khayat, Shirly Amar, Atalia Shtorch- Asor, Jumana Haddad Halloun, Sarit Farage Barhom, Daphne Chapman Shimshoni, Dana Brabbing-Goldstein, Maria Karter, Yael Avigdor, Isabelle Espanioly, Valerie Drasinover, Olga Krivoruk, Harel Zalts, Rivka Sukenik-Halevy, Shira Litz Philipsborn, Ran D Balicer, Shay Ben-Shachar
Journal of Medical Gentics
2026
N-terminal truncating variants in CACNB1 cause a new congenital muscular disorder
Asier Iturrate, Nurit Assia Batzir, Ranit Jaron, David Garcia-Valentin, Julian Nevado, Jair Tenorio-Castano, Pablo Lapunzina, Kamila Lee, Rotem Greenberg, Dvora Sassi, Sharon Aharoni, Alla Kuzminsky, Lina Basel-Salmon, Naama Orenstein, Yakov Fellig, Shay Ben-Shachar, Dina Marek-Yagel, Victor L Ruiz-Perez
European Journal of Human Genetics
2026
Mono and Biallelic Variants in TRIM63 Are Frequently Associated With a Unique Form of Hypertrophic Cardiomyopathy
Noa Ruhrman Shahar, Dina Marek-Yagel, Rotem Greenberg, Ofer Isakov, Michal Naftali, Elena Friedman, Lily Bazak, Daniel Monakier, Alvit Veber, Nechama Shalva, Amitai Segev, Moti Haim, Lena Sagi-Dain, Lilach Benyamini, Adel Shalata, Sagi Josefsberg Ben Yehoshua, Lina Basel Salmon, Sara Hoss, Shay Ben-Shachar
Circulation: Genomic and Precision Medicine
2025
Characterization of the indications for performing gene panel sequencing tests in a genomic center
Rotem Greenberg, Ofer Isakov, S Ben Shahar, Lena Sagi-Dain
Harefuah
2023
The Ivan and Francesca Berkowitz Family Living Laboratory
Untangling the precise factors that underlie medical mysteries can illuminate individualized treatments based on a person’s genetic predispositions, immune profile, health history, and lifestyle. Such insights can propel forward the science and practice of precision medicine and have a profound effect on human health.
In a decisive step forward on this quest, Harvard Medical School in Boston and Clalit Research Institute in Tel Aviv have launched a joint precision medicine effort, enabled by a donation from the Berkowitz family.
We have established The Ivan and Francesca Berkowitz Family Living Laboratory Collaboration at Harvard Medical School and Clalit Research Institute. The program has two arms:
- The Ivan and Francesca Berkowitz Family Living Laboratory at HMS.
- The Ivan and Francesca Berkowitz Family Precision Medicine Clinic at Clalit.
The two arms work together to conduct joint research. They also feature a clinical component that provides diagnosis and care for patients with rare, undiagnosed, and hard-to-treat conditions, in addition to research.
We Are Visionaries
Our vision of precision medicine is possible thanks to technological advances that enable rapid sequencing and decoding of the human genome. Along with this, the development of advanced computing capabilities enables the analysis of various types of data in very large amounts (Big Data).
Clalit's new genomic center was established as a significant part of this innovative medical vision and gives our clients a much faster and more professional response due to the center's close interface with the clinical staff.
We provide whole exome and whole genome sequencing, advanced bioinformatics and genomic variants’ analysis:
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Sequencing and bioinformatics services
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Genetic population studies/ specific disorders
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Retrospective genomic control groups