Hidradenitis suppurativa (HS) is a chronic inflammatory disorder characterized by recurrent painful nodules, abscesses, sinus tract formation, and scarring, most commonly affecting intertriginous areas. Although most cases are multifactorial, a subset of patients with early-onset, familial, severe, or syndromic disease may have an identifiable monogenic cause or genetic predisposition.

This panel includes genes associated with familial hidradenitis suppurativa, disorders of γ-secretase signaling, and selected follicular occlusion and autoinflammatory syndromes that may present with hidradenitis-like disease.

This panel is recommended for patients with severe, early-onset, familial, or syndromic hidradenitis suppurativa, particularly when accompanied by acne conglobata, pyoderma gangrenosum, sterile arthritis, or other inflammatory or follicular-occlusion manifestations.