Idiopathic or genetic epilepsies comprise a group of epilepsy syndromes in which seizures occur without an identified acquired structural cause and in which genetic factors are considered to play an important role. These disorders may include generalized as well as selected focal or non-lesional epilepsy syndromes and often occur in individuals without major developmental abnormalities.

This panel includes genes associated with genetic generalized and other non-lesional epilepsies, particularly disorders affecting neuronal ion channels, synaptic transmission, and other pathways involved in neuronal excitability.

This panel is recommended for patients with suspected genetic epilepsy in the absence of a clear acquired structural cause, particularly when brain imaging is normal and there is no significant developmental delay or broader syndromic phenotype. Compared with the broader GC_23 – Epilepsy panel, this focused panel is preferred when epilepsy appears to be the primary or isolated clinical manifestation.